منابع مشابه
Too much or too little
The global effort to understand the molecular drivers of cancer onset and progression is now coming to fruition with the identification of specific genomic and epigenomic events that influence signaling through key oncogenic pathways. Genetic studies using inducible expression of the critical growth controlling oncogenes MYC, RAS, PI3K and AKT have shown unequivocally that, in conjunction with ...
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Across two studies, we asked whether people trust too much or too little, relative to what an economic analysis would suggest. In the trust game paradigm, participants decided whether to hand money over to an anonymous individual who could either return more money back or keep all the money. Participants trusted too little, in that they grossly underestimated the proportion of their peers who w...
متن کاملBiologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?
We describe the development and approval of biologically targeted agents in the clinic through examples chosen from the experience with inhibitors of the epidermal growth factor (EGF) and VEGF pathways. Despite extensive biological rationale for the use of these classes of molecules, marginal clinical benefits have been observed in broad patient populations, and the agents have entered into gen...
متن کاملRingler Too much or too little water in the Mekong ?
Prof. Andreas Wimmer Director at ZEF Since the end of the cold war, the development policy debate has undergone a remarkable transformation. Whereas before, the political and legal environment of a developing country has been scarcely taken into consideration, today human rights, good governance, the rule of law and democracy, peaceful conflict settlement etc. have become central elements of de...
متن کاملNoradrenergic function and depression, too much or too little?
Antithetical hypotheses as to CNS noradrenergic function in depressed patients can be constructed from results of pharmacological studies of the effects of antidepressant drugs. The experimental data supporting each of these opposing propositions is briefly reviewed in this paper. Finally, the results of clinical studies of noradrenergic function in depressed patients are noted and discussed in...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2014
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2013.12.542